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In addition, the need for improved delivery strategies indicates that these compounds still require significant optimisation before being considered competitive therapeutic candidates relative to established drugs such as cisplatin

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Thus, heterosynaptic changes in inhibitory neurons were weight-dependent: Inputs with initially high paired-pulse ratio (low release probability, weak inputs) tended to be potentiated while inputs with initially low paired-pulse ratio (high release probability, strong synapses) tended to depress or did not change after intracellular tetanization